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The Krebs Cycle
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Slide 1

The Krebs Cycle

The Krebs Cycle

Occurs in the matrix of the mitochondrion

Aerobic phase (requires oxygen)

2-carbon acetyl CoA joins with a 4-carbon compound to form a 6- carbon compound called Citric acid

Slide 2

Citric acid (6C) is gradually converted back to the 4-carbon compound

Citric acid (6C) is gradually converted back to the 4-carbon compound

-ready to start the cycle once more

The carbons removed are released as CO2

-enzymes controlling this process called decarboxylases

The hydrogens, which are removed, join with NAD to form NADH2

-enzymes controlling the release of hydrogen are called dehydrogenases

Slide 3

The Krebs Cycle

Slide 4

The Cytochrome System

The Cytochrome System

6 points along pathway where hydrogen is released and temporarily bound to NAD

Reduced coenzyme NADH2 transfers hydrogen to a chain of hydrogen carriers called cytochrome system

These systems are attached to the cristate of every mitochondrion

Slide 5

Transfer of hydrogen from each NADH2 along system

Transfer of hydrogen from each NADH2 along system

-produces 3 ATP

-process called oxidative phosphorylation

Complete oxidation of glucose yields 38 ATP

-2 during glycolysis

-36 during oxidative phosphorylation

Slide 6

The Cytochrome System

Slide 7

The role of oxygen

The role of oxygen

Final hydrogen acceptor

Combines to form water

Controlled by enzyme cytochrome oxidase

Presence of oxygen also essential for hydrogen to pass along the cytochrome system

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