Seminar on Transplantation Immunology: Organ and Tissue Transplantation Immunosuppressive Agents, Immunosuppressive Therapy.
Mr.Pratap J. Patle
Deptt. Of Zoology
R.T.M. Nagpur University, Nagpur
Immunology of Transplant Rejection
Tissue and Organ Transplantation
Transplantation immunology - sequence of events that occurs after an allograft or xenograft is removed from donor and then transplanted into a recipient.
A major limitation to the success of transplantation is the immune response of the recipient to the donor tissue.
Autograft is self-tissue transferred from one body site to another in the same individual.
Isograft is tissue transferred between genetically identical individuals.
Allograft is tissue transferred between genetically different members of the same species.
Xenograft is tissue transferred between different species
Components of the Immune system involved in graft Rejection :
1) Antigen presenting cells –
Activated B Cells
2) B cells and antibodies –
Preformed antibodies from prior sensatization
3) T cells
4) Other cells –
Natural killer cells
T cells that express NK cell – associated Markers
Recognition of transplanted cells that are self or foreign is determined by polymorphic genes (MHC) that are inherited from both parents and are expressed co-dominantly.
Alloantigens elicit both cell-mediated and humoral immune responses.
Recognition of an intact MHC molecule displayed by donor APC in the graft
Basically, self MHC molecule recognizes the structure of an intact allogeneic MHC molecule
Involves both CD8+ and CD4+ T cells.
Donor MHC is processed and presented by recipient APC