DNA polymerase a has associated primase activity and is thought to be the polymerase that synthesizes the lagging strand.
PCNA (proliferating cell nuclear antigen)
Replication factor C
Eukaryotic DNA is packaged with histones in structures called nucleosomes.
What happens to the nucleosome when the replication fork and the replication machinery pass by and open up the DNA double strand?
Nucleosomes are found properly spaced on both postreplicative DNA strands immediately after passage of replication fork.
A model for nucleosome replication
The lagging strand of telomeres cannot be replicated by the usual mechanism
special telomere sequence: tandem repeats of TTAGGG (human)
telomerase, a specific enzyme with integrated RNA template.