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Chromosome
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Clinical Syndrome: Klinefelter

Estimated Frequency Birth: 1/500 male borth

Main Phenotypic Characteristics:

Pitched voice, Male, subfertile with small testes, developed breasts, feminine, long limbs.

Slide 95

Found in certain tissues e.g., salivary glands of larvae, gut epithelium, Malphigian tubules and some fat bodies, of some Diptera (Drosophila, Sciara, Rhyncosciara)

Found in certain tissues e.g., salivary glands of larvae, gut epithelium, Malphigian tubules and some fat bodies, of some Diptera (Drosophila, Sciara, Rhyncosciara)

These chromosomes are very long and thick (upto 200 times their size during mitotic metaphase in the case of Drosophila)

Hence they are known as Giant chromosomes.

Giant chromosomes

Slide 96

They are first discovered by Balbiani in 1881 in dipteran salivary glands and thus also known as salivary gland chromosomes.

They are first discovered by Balbiani in 1881 in dipteran salivary glands and thus also known as salivary gland chromosomes.

But their significance was realized only after the extensive studies by Painter during 1930’s.

Giant chromosomes have also been discovered in suspensors of young embryos of many plants, but these do not show the bands so typical of salivary gland chromosomes.

Slide 97

He described the morphology in detail and discovered the relation between salivary gland chromosomes and germ cell chromosomes.

He described the morphology in detail and discovered the relation between salivary gland chromosomes and germ cell chromosomes.

Slides of Drosophila giant chromosomes are prepared by squashing in acetocarmine the salivary glands dissected out from the larvae.

The total length of D.melanogater giant chromosomes is about 2,000µ.

Slide 98

Giant chromosomes are made up of several dark staining regions called “bands”.

Giant chromosomes are made up of several dark staining regions called “bands”.

It can be separated by relatively light or non-staining “interband” regions.

The bands in Drosophila giant chromosome are visible even without staining, but after staining they become very sharp and clear.

In Drosophila about 5000 bands can be recognized.

Slide 99

Some of these bands are as thick as 0.5µ, while some may be only 0.05µ thick.

Some of these bands are as thick as 0.5µ, while some may be only 0.05µ thick.

About 25,000 base-pairs are now estimated for each band.

All the available evidence clearly shows that each giant chromosome is composed of numerous strands, each strand representing one chromatid.

Therefore, these chromosomes are also known as “Polytene chromosome”, and the condition is referred to as “Polytene”

Slide 100

The numerous strands of these chromosomes are produced due to repeated replication of the paired chromosomes without any nuclear or cell division.

The numerous strands of these chromosomes are produced due to repeated replication of the paired chromosomes without any nuclear or cell division.

So that the number of strands (chromatids) in a chromosome doubles after every round of DNA replication

It is estimated that giant chromosomes of Drosophila have about 1,024 strands

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